Hver af de 40 plus ørken feriesteder, beachfront villaer og skihytter forvaltes af Destination Hotels Resorts fremkalder geografi en bestemt region af landet gennem indretning: L’Auberge del Mar har udsigt Californiens dramatiske seaside landskab, mens Vail Cascade Resort Spas opvarmede pools, ski in / ski out adgang og indbydende Fireside Bar tilbyder hyggelige retreats fra Vail s winterscapes. Uanset placering, Destination egenskaber understrege afslapning og rekreation (ofte i form af kurbade og golfbaner), og hver ejendom indeholder konferencefaciliteter. Følgende Destination Hotels Resorts holder pletter på vores bedste hoteller i USA placeringer.
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Royal Palms Resort and Spa har trukket mange en VIP herunder præsident George W. Bush tilbage i 2004 på grund af sin intime, luksuriøs atmosfære. Værelserne her ser ud som om de tilhører i en elite tex ejendom, praler levende, juvel tonet udsmykning, dybe badekar og hånd valgt møbler. Afhængigt af, når du besøger, kan ejendommens poolområdet føler lidt overfyldt (og blokering en lounge stol kan være svært), men det giver tiltrængt pusterum fra den brændende Arizona varme. Open air Alvadora Spa er også nice; den udendørs regnbruser eliminerer enhver stress, besøgende kan bringe med sig. I mellemtiden, den udendørs spiseplads på T. Cooks giver en dejlig stemning for restaurantens dristige varianter. Mange værelser har udsigt til Stillehavet fra altaner og er udstyret med en lang liste af luksus faciliteter, herunder LCD fladskærms-tv, fire armatur sten badeværelser og iPod-dockingstation. Men de fleste gæster sætter pris hvad der er uden for deres kvarterer, især fitnesscenter og flere puljer. Hotellet huser også en bemærkelsesværdig spa, og besøgende er i ærefrygt af de ekspansive, velplejede grunde alle 102 acres. Dette venlige feriested (forvaltet af Destination Hotels Resorts) familyand kæledyr har otte lækre spisesteder og vandhuller. Så naturligvis, gæster rave om de ærefrygt inspirerende udsigt over områdets glitrende søer og herlige toppe. En anden stor fordel: Den gondol til skråninger af Mount Mansfield og Spruce Peak er kun få skridt fra hotellets dør. Faciliteterne er skræddersyet til pulveret jagthunde der er endda en ski og snowboard kammertjener men ikke-skiløbere kan værdsætte stenen indkapslet pejse, den opvarmede udendørs swimmingpool og de to usædvanlige i hus spisesteder. Gæsterne ros også de behandlinger, der tilbydes på The Spa at Stowe Mountain Lodge, hvoraf mange er inspireret af amerikanske indiske traditioner. Den udvej er kæledyrsvenligt, indbydende firbenede venner vejer op til 100 pounds. I foyeren ligner en scene fra en renæssance maleri, med hvælvede døråbninger, tårnhøje søjler, fløjlsagtig møbler og fejende vægmalerier. Værelserne, på den anden side, er farverige og finurlige med stribede vægge og blomster accenter. Hotellet (tidligere Hotel Monaco San Francisco) tilbyder moderne bekvemmeligheder såsom LCD fladskærms-tv, iHome stereoanlæg og ære barer. Gæster rave om indretningen, men de gør sikker på at spare nogle komplimenter for det venlige hotel personale og velsmagende retter serveres på den nye BDK Restaurant Bar. Besøgende er også glad for gratis morgenkaffe og aften vin receptioner i lobbyen. Og dem med firbenede venner behøver ikke lade dem derhjemme. Grundlæggende faciliteter inkluderer gratis Raid Pantry late night snacks, hyggeligt på værelset chenille kast, 42 tommer fladskærms-tv og Molton Brown toiletartikler. Og så er der Woody Meg, hotellets kæledyr Labrador retriever, officielle direktør for Barketing og vært for hunden venlige yappier timer (afholdt den tredje mandag i hver måned juni til september). Nylige rejsende var virkelig imponeret med deres middag på Bin på søen restaurant og stjernernes service personale i hele hotellet. The Beach Cafe er en anden havnefronten spisning indstilling som gæster elsker for sin friske udvælgelse fisk. Francis Cathedral), men du vil stadig ønsker at reservere tid til at udforske hotellet. Gæsterne har værelserne, som sætter en moderne spin på Southwest indretning med lyse røde nuancer og beige accenter, samt fladskærms-tv og luksuriøse badeprodukter. Nogle af værelserne har endda privat balkon med udsigt over byen (selvom du bliver nødt til at være villig til at betale ekstra for udsigten). Mens her, vil du ikke ønsker at gå op for muligheden for at slappe af på Spa at Loretto, som gennemsyrer indianske healing teknikker i sine behandlinger. Og som dagen går på hæld, seneste gæster tyder stærkt udgifter middagstid på Luminaria, som tilbyder en innovativ tage på Santa Fe køkken, før opsigtsvækkende cocktails i The Living Room lounge. Beliggende i vest Vail, dette året rundt resort tilbyder KidVenture, en bred vifte af medarbejdere overvågede aktiviteter rettet specifikt mod børn i alderen 5 til 12; der er også børnepasning og convenience emner som krybber og høje stole. Og fordi denne medlem af Destination Hotels Group forstår, at Fido er en del af familien, også dine firbenede venner er mere end velkomne til at blive. Værelserne er helt sikkert store nok til at passe hele klanen, mens i værelse film og videospil vil holde de små indhold om aftenen. Når det er varmt nok, tilbringe et par timer nyder visningen af ​​Gore Creek fra på stedet infinity pool før at tackle det omgivende vandre-og cykelruter. I mellemtiden er den på stedet Aria Spa tjener en stor tommelfingeren fra de seneste gæster mange forældre nævner, at det er det ideelle sted at fordrive tiden, mens børnene er off eventyr. Gennem concierge, kan besøgende planlægge alt fra ridning til rafting og klatring til mountainbike. Plus, Sunriver prale en forbløffende 63 huller på golfbanen. Om vinteren, kan hotellets gæster tage den gratis shuttle til foden af ​​Mount Bachelor til prime skiløb terræn. Efter en lang dag med aktiviteter, rejsende nyde deres tid i Sage Springs Club Spa og deres måltider på nogen af ​​de seks spisesteder. De to muligheder deler faciliteter; Men som omfatter legeplads, Frisbee golf og regelmæssige golfbaner, stort poolområde, veludstyret fitnesscenter og Swiftwater Cellars Winery. Gæsterne kan også nyde den på stedet spa eller deltage i sæsonbetonede begivenheder som Winterfest og Harvest Festival. Wild Dunes er også en fornøjelig familie stedet. Børn kan tage tennis og golf lektioner og få del i kunst og kunsthåndværk projekter. De kan også deltage i rejsendes foretrukne Island Adventures aktiviteter, som omfatter naturoplevelser, ligesom Kapers Island Wildlife Exploration. Lodgers opfordres også til at borde et skib på vej til Capers Island, med observationer af mose dyreliv undervejs. Når du ikke er på farten, trække sig tilbage til dine rejsearrangementet på enten Boardwalk Inn eller Village på Wild Dunes, som alle har kaffemaskiner, fladskærms-tv og tæt på stranden. Tidligere gæster havde det meste ros for Wild Dunes Resort, citerer alt fra de komfortable værelser til den velsmagende på stedet mad som årsager til en tilbagevenden besøg. Nogle rejsende, men sagde, at de mødte vanskelige receptionen medlemmer, og bemærkede, at personalet som helhed kunne bruge nogle ekstra uddannelse.

First, my concern was whether or not I should continue to own it as it thrashes through the process of enduring a key patent expiration on Humira, the blockbuster drug which accounts for 60% of its sales. I researched the company and published an article expressing my ambivalence towards it. Rather than writing and forgetting, I wrote and continued researching.

As I did so and evaluated AbbVie’s prospects under diverse scenarios, I concluded that it was definitely best to hold tight. There is no opportunity in the market today which offers a better safer repository for the proceeds if I were to sell.

AbbVie’s Humira sales dominance is not just a source of risk to the company. It also gives AbbVie the financial firepower to manage its way to “deconcentrate from Humira.” This is the marvelous phrase that Bill Chase, AbbVie’s CFO and Executive Vice President, used at his May 23, 2016, presentation at the UBS Global Healthcare Brokers Conference to describe AbbVie’s efforts to round out its portfolio. AbbVie is definitely not a stock where management fails to “get it.” Three SA news pieces last week are highly illustrative of AbbVie’s good work towards this end.

1. SA News from Tuesday, May 24, 2016: “Boehringer’s risankizumab induces remission in Crohn’s patients in mid stage study”

An important part of AbbVie’s deconcentration efforts are its ongoing programs of reaching out and partnering with other pharmaceutical companies to expand its pipeline. As recently as March 7, 2016, AbbVie announced its collaboration with Boehringer Ingelheim to advance immunology compounds, particularly as directed to Crohn’s disease and plaque psoriasis among others.

Now a phase 2 trial of the compound risankizumab is reporting favorable interim results on its path to completing the 52 week study expected to wind up in December of this year.

Boehringer Ingelheim’s website describes the deal as follows:

“. a global collaboration with AbbVie for BI 655066 and BI 655064, Boehringer Ingelheim’s two most advanced development compounds in immunology. The agreement will ensure that the two compounds can be brought forward to benefit more patients from the moment of launch, optimising the availability worldwide.AbbVie, a company with extensive experience in the immunology field, will ensure BI 655066 and BI 655064 reach their full potential to help patients across the globe, while Boehringer Ingelheim expands its capabilities in this new therapeutic area.

Both companies will share the responsibility for Phase III development of BI 655066 in the initial period and Boehringer Ingelheim will retain rights to co promote BI 655066 in asthma. Boehringer Ingelheim will also have the responsibility for further development of BI 655064, with AbbVie may elect to advance the programme after achievement of undisclosed certain clinical milestones.”

The outline of the deal required an initial payment by AbbVie of $595 million. Additional milestone payments and license fees are also envisioned but terms thereof have not been disclosed.

2. SA News from May 27, 2016: “European Ad Comm backs new use of AbbVie’s Humira for type of eye inflammation”

Ironically, continued development of Humira is a key component of the process of deconcentrating AbbVie. Humira is the goose that keeps laying golden eggs. AbbVie needs to continue its ongoing process of building up revenues from this marvelous creation. Such revenues give it the war chest that enable it to make milestone payments to companies like Boehringer Ingelheim. They also enable AbbVie to borrow billions on favorable terms when the occasion warrants.

In addition, the more revenue streams that flow from Humira, the less each single competitor will threaten AbbVie, until it too is able to prove its efficacy to combat that particular condition. AbbVie’s management has grown an impressive patent estate of no fewer than 70 patents, protecting various aspects of the drug from competition.

3. SA News also from May 27, 2016: “FDA OKs long acting MS biologic daclizumab”

As pointed out in the news item, daclizumab (Zinbryta) is a long acting MS drug. AbbVie acquired co promotion rights in the United States and the EU in 2010 when it acquired Facet Biotech. Apparently, AbbVie became involved as something of a white knight, offering a premium over a lower hostile bid that Biogen had made for Facet. Now, some 6 years later, the deal will start to pay off.

It is worthwhile to read the comments to the SA news article. DoctoRx points out the difficulties the drug will have in finding traction by reason of its black box warning and the death that occurred during clinical trials. Several others push back, citing the paucity of alternatives that MS patients face when it comes to therapies that lack equally daunting risk profiles.
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Conclusion: Deconcentration is a Process

One thing that is clear from reading these news items is that AbbVie will not replace any Humira revenues that may occur quickly or easily. It is a tribute to AbbVie’s management that it has painstakingly developed the pipeline that it has, piece by piece and step by step, all the while protecting and expanding Humira, the Mother Goose who has laid the golden eggs.

Disclosure: I am/we are long ABBV.

I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

On three separate occasions in the past 30 years the country’s largest guerrilla group and a succession of governments have sat down to peace talks, and failed.

Some experts argue that since Santos pulled back from the hard line of his predecessor, the political and military landscape now favors a peace deal. “In conflict resolution negotiations happen . when a stalemate is viewed as mutual,” says Aldo Civico, an expert on the conflict at Rutgers University in New Jersey who has facilitated cease fire talks with another Colombian guerrilla group, the National Liberation Army, in the past. “Both sides are aware they won’t defeat their enemy militarily,” he says.

While Colombia is considered a rising economic power, its internal conflict holds it back, says Mr. Civico. Rebels have targeted key industries, with attacks on oil pipelines more than quadrupling in the first seven months of 2012, according to the Defense Ministry. Nearly 4 percent of gross domestic product went to military expenditures between 2007 and 2011; US defense aid is falling. Colombia needs to redirect its resources to closing the poverty gap, fighting urban violence, and luring foreign investment, says Civico.

Santos’s approval rating has plunged over the past year from 71 percent to 47 percent, in part because of security issues, according to Colombia’s Semana magazine. He aims to improve his standing as he enters the second half of his term, perhaps even trying to create a legacy as the “president of peace,” Civico says.

The FARC also has reasons to talk. After losing many top leaders, achieving its goals by force seems unlikely. “The peace process is an opportunity to increase the FARC’s political profile to remind everyone that they have political discourse behind the guerrilla [tactics],” Civico says.
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In the aftermath of a disaster such as superstorm Sandy, two way communication is essential. People need to be able to receive news and updates, and to request assistance and provide status updates to loved ones.

Yet after hurricane Sandy, large portions of New York, New Jersey, and other areas lost their communication systems their mobile phone network, cable TV, and Internet. Some sought out the last few pay phones as the only equipment that worked.

Above all, America’s telecommunications system depends on the electric grid. It is possible to protect the grid by burying power lines and creating alternate lines of supply. The cost of this should be balanced with the benefits of improved reliability and safety.

Alternatively, we could place permanent backup generators at each cell site, effectively isolating them from the power grid. But that just changes the nature of the challenge to one of distributing fuel to the site’s generators. As we saw in the aftermath of Sandy, even procuring fuel can be difficult after a disaster.

The aim should not be to fully counter each situation, but to focus instead on making the communications system more resilient. We need to take steps that would make the communications system capable of operating at a predetermined level of usefulness even in the face of some loss of capacity.

Les formes courantes de l’arthrite comprennent l’arthrose, causée par l’usure sur les articulations; la polyarthrite rhumatoïde, une maladie auto-immune dans laquelle le corps attaque ses propres articulations; et la goutte, causée par une accumulation d’acide urique dans le corps. Chaque livre de l’excès de poids met 4 livres de stress supplémentaire sur vos genoux. Et la graisse elle-même crée des produits chimiques qui peuvent aggraver l’inflammation, ce qui explique pourquoi les personnes obèses sont également plus à risque de l’arthrite dans les mains. L’obésité est liée à l’arthrite rhumatoïde et la goutte ainsi, dit la Fondation Arthritis. La réduction sur les aliments qui sont chargés avec des graisses et des sucres, en particulier des calories vides comme la soude ou des aliments qui vous incitent à trop manger, pouvez aider à décoller livres.

Les aliments cuits à haute température

Produits avancés de glycation, ou AGEs, sont des substances présentes dans de nombreux aliments, les aliments gras particulièrement élevés, les aliments et les aliments transformés qui sont frits, grillés, Microwaved ou cuits. Bien que les aliments chargés de AGEs ne sont pas directement liées à l’arthrite, la réduction sur eux peut aider à lutter contre l’inflammation, le rapport des chercheurs de la Mount Sinai School of Medicine. Dans un article paru dans le «Journal of the American Dietetic Association, les chercheurs ont noté que vous pouvez réduire les AGEs en mangeant plus de poisson, des légumes, des fruits, des céréales et des produits laitiers à faible teneur en matières grasses et moins de viandes et riches en matières grasses des produits laitiers. Certaines personnes atteintes de polyarthrite rhumatoïde ont rapporté que les produits laitiers, les fruits d’agrumes ou de plantes de la famille des solanacées telles que les pommes de terre ou de piments aggravé les symptômes de l’arthrite. Il peu de science pour appuyer cela, rapporte la Fondation Arthritis, mais une étude de 2006 rapportée dans n’a trouvé des niveaux que de nombreux patients atteints de polyarthrite rhumatoïde ont élevés d’anticorps à des aliments, y compris les produits laitiers, le soja, la morue, le porc, les œufs et les céréales. Les chercheurs ont émis l’hypothèse que les sensibilités alimentaires peuvent aggraver les réactions auto-immunes dans la polyarthrite rhumatoïde.
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Aliments riches purine et l’alcool

Si la goutte est le problème, réduire les aliments riches en purines, car ils provoquent une augmentation de l’acide urique. Les aliments riches en purine comprennent les anchois, les asperges, les abats, le hareng, le maquereau, les sardines, les pétoncles et les haricots secs et les pois. L’alcool peut également augmenter l’acide urique, selon les National Institutes of Health .